ABSTRACT Klebsiella pneumoniae is an important cause of multidrug-resistant infections worldwide. Understanding the virulence mechanisms of K. pneumoniae is a priority and timely to design new therapeutics. Here, we demonstrate that K. pneumoniae limits the SUMOylation of host proteins in epithelial cells and macrophages (mouse and human) to subvert cell innate immunity. Mechanistically, in lung epithelial cells, Klebsiella increases the levels of the deSUMOylase SENP2 in the cytosol by affecting its K48 ubiquitylation and its subsequent degradation by the ubiquitin proteasome. This is dependent on Klebsiella preventing the NEDDylation of the Cullin-1 subunit of the ubiquitin ligase complex E3-SCF-βTrCP by exploiting the CSN5 deNEDDylase. K...
Phagocytosis is a key process of the immune system. The human pathogen Klebsiella pneumoniae is a we...
ABSTRACT Klebsiella pneumoniae is an urgent public health threat because of resistance to carbapenem...
One of the main bactericidal mechanisms of polymorphonuclear neutrophils (PMN) is the release of neu...
[eng] Klebsiella pneumoniae is an important cause of community-acquired and nosocomial pneumonia. Su...
Klebsiella pneumoniae is an etiologic agent of community-acquired and nosocomial pneumonia. It has b...
Klebsiella pneumoniae is an important cause of community-acquired and nosocomial pneumonia. Evidence...
[eng] The NF-kB transcriptional factor plays a key role governing the activation of immune responses...
[[abstract]]The Gram-negative bacterium Klebsiella pneumoniae can cause septicemia, pneumonia, liver...
[eng] Airway epithelial cells act as the first barrier against pathogens. These cells recognize cons...
ABSTRACT Antibiotics and vaccines have greatly impacted human health in the last century by dramatic...
During infection, pathogenic bacteria manipulate the host cell in various ways to allow their own re...
Klebsiella pneumoniae is an opportunistic pathogen that causes several kinds of infections, includin...
[[abstract]]Klebsiella pneumoniae raises significant concerns to the health care industry as these m...
The epidemic clone of Klebsiella pneumoniae (Kpn), sequence type 258 (ST258), carbapenamase producer...
The epidemic clone of Klebsiella pneumoniae (Kpn), sequence type 258 (ST258), carbapenamase producer...
Phagocytosis is a key process of the immune system. The human pathogen Klebsiella pneumoniae is a we...
ABSTRACT Klebsiella pneumoniae is an urgent public health threat because of resistance to carbapenem...
One of the main bactericidal mechanisms of polymorphonuclear neutrophils (PMN) is the release of neu...
[eng] Klebsiella pneumoniae is an important cause of community-acquired and nosocomial pneumonia. Su...
Klebsiella pneumoniae is an etiologic agent of community-acquired and nosocomial pneumonia. It has b...
Klebsiella pneumoniae is an important cause of community-acquired and nosocomial pneumonia. Evidence...
[eng] The NF-kB transcriptional factor plays a key role governing the activation of immune responses...
[[abstract]]The Gram-negative bacterium Klebsiella pneumoniae can cause septicemia, pneumonia, liver...
[eng] Airway epithelial cells act as the first barrier against pathogens. These cells recognize cons...
ABSTRACT Antibiotics and vaccines have greatly impacted human health in the last century by dramatic...
During infection, pathogenic bacteria manipulate the host cell in various ways to allow their own re...
Klebsiella pneumoniae is an opportunistic pathogen that causes several kinds of infections, includin...
[[abstract]]Klebsiella pneumoniae raises significant concerns to the health care industry as these m...
The epidemic clone of Klebsiella pneumoniae (Kpn), sequence type 258 (ST258), carbapenamase producer...
The epidemic clone of Klebsiella pneumoniae (Kpn), sequence type 258 (ST258), carbapenamase producer...
Phagocytosis is a key process of the immune system. The human pathogen Klebsiella pneumoniae is a we...
ABSTRACT Klebsiella pneumoniae is an urgent public health threat because of resistance to carbapenem...
One of the main bactericidal mechanisms of polymorphonuclear neutrophils (PMN) is the release of neu...